Malignancy Associated with Low-Risk HPV6 and HPV11: A Systematic Review and Implications for Cancer Prevention

High-risk human papillomavirus (HPV) is etiologically related to cervical cancer, other anogenital cancers and oropharyngeal carcinomas. Low-risk HPV, especially HPV6 HPV11, cause genital warts laryngeal papillomas. However, the accumulating data suggests that HPV11 may malignant lesions at non-cervical anatomic sites. This review aims estimate proportions of single dual HPV6/11 infections in multiple reported last 10 years Cochrane, Embasa PubMed databases. Secondly, genomes were compared with most common high-risk genotype, HPV16, determine similarities differences. A total 11 articles selected, including between one 334 HPV+ cancer patients. The frequencies or ranged 0–5.5% for penile 0–87.5% null vulvar, vaginal oral cancers. genomic HPV16 mainly involved E7 gene, indicating a limited ability block cell differentiation. presence variable support vaccination strategies cover these genotypes, not only preventing but also prevention. Other risk factors co-carcinogens are likely participate epithelial carcinogenesis associated low-risk HPV.